GSK4716 Powder

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GSK4716 powder is a small-molecule compound that acts as a modulator of estrogen-related receptors (ERRs), primarily functioning as a selective agonist for ERRβ and ERRγ. GSK 4716 binds to ERRβ and ERRγ receptors and regulates ERR signaling pathways. It increases their transcriptional activity, affecting the expression of genes related to cellular energy metabolism, mitochondrial function, lipid metabolism, glucose utilization, and cellular homeostasis. Unlike classical estrogen receptors, ERR family members are a distinct class of nuclear receptors whose activity is closely linked to systemic energy metabolism and cellular metabolic networks. Due to its well-defined selectivity for ERRβ and ERRγ, GSK 4716 is highly valuable in fields such as nuclear receptor signaling, metabolic regulation, molecular biology, cell biology, and pharmacology; it serves primarily as a small-molecule tool for investigating ERRβ/ERRγ function and downstream regulatory mechanisms, offering a means to modulate these processes at the molecular level in metabolic signaling research. If you want to learn more about the GSK4716 compound supplier, contact Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu Biotech Co., Ltd is a peptide raw material supplier with peptide technology at its core and an international market orientation. Sonwu specializes in the R&D, production, and global supply of functional peptides and polypeptide raw materials. Sonwu's products are widely applied in multiple fields, including muscle building, beauty and anti-aging, hair health, weight management, nootropics, and pharmaceutical raw materials.

Sonwu's products have been widely used in customers' R&D and industrialization projects worldwide. As a result, Sonwu has received extensive feedback on its products. If you need the GSK4716 compound, please contact Xi'an Sonwu.

Xi'an Sonwu provides large-scale production services and can also provide sample packages to customers first.

Xi'an Sonwu not only supplies high-quality GSK4716 powder but also offers customized products to meet customer needs.

Firstly, for customized products, customers need to provide information such as the product's CAS number and synthesis route. Sonwu will help you confirm whether customization is possible based on your requirements or provide professional suggestions.

Second, for customized packaging, Sonwu offers a minimum packaging size of 1g and can provide customized packaging upon request.

1. Modulating the ERRβ/ERRγ nuclear receptor signaling pathway
GSK 4716 is a strong agonist of both estrogen-related receptors γ (ERRγ) and β (ERRβ). ERRβ and ERRγ, members of the nuclear receptor superfamily, influence the transcriptional activity of specific genes and participate in a range of biological functions. GSK 4716 affects downstream transcriptional regulatory networks by engaging these receptors and promoting a more active receptor state. Because ERR signaling is closely linked to tissue function, metabolic equilibrium, and cellular energy utilization, GSK 4716 is often utilized to modify and clarify ERRβ/ERRγ-related signaling pathways. GSK 4716 is a representative tool for nuclear receptor regulation because of its unique profile of action on ERRβ and ERRγ, in contrast to substances that directly target conventional estrogen receptors.
2. Regulating energy metabolism and mitochondrial function

The ERR family is closely linked to cellular energy metabolism networks, particularly processes involving mitochondrial function, oxidative metabolism, and maintaining cellular energy supply. By activating ERRβ/ERRγ-mediated transcription, GSK 4716 influences the regulation of genes associated with energy metabolism, thereby modulating cellular metabolic states. Because ERR signaling bridges nuclear receptor-mediated regulation and mitochondrial function, GSK 4716 is a valuable chemical tool for investigating cellular metabolic regulatory networks. Its mechanism of action extends beyond altering specific metabolite levels; instead, it influences a cascade of related molecular processes through receptor-mediated transcriptional regulation. This characteristic makes GSK 4716 highly significant for research in areas such as energy metabolism, mitochondrial biology, and cellular homeostasis.

3. For use in the fields of metabolic signaling and nuclear receptors

GSK 4716 also enables targeted molecular regulation of biological processes involving ERRβ and ERRγ. Modulating ERR activity makes it easier to examine relationships among metabolic signaling pathways because ERR receptors are widely implicated in oxidative metabolism, glucose utilization, lipid metabolism, and cellular energy homeostasis. GSK 4716 is widely used in nuclear receptor biology, molecular biology, cellular metabolism, mitochondrial function, and pharmacology because it is a well-defined agonist of ERRβ and ERRγ. It mainly serves as a pharmacological tool to modulate ERR signaling in these contexts, allowing researchers to examine how changes in receptor activity affect related transcriptional networks and physiological processes. Furthermore, GSK 4716 serves as a reference compound in the development and structural optimization of ERR modulators, providing a foundation for designing related small molecules.

1. Activation of ERRβ/ERRγ Receptors

The primary mechanism of action of GSK 4716 is to function as an agonist for estrogen-related receptor β (ERRβ) and estrogen-related receptor γ (ERRγ). ERRβ and ERRγ belong to the nuclear receptor family; with both ligand-binding and DNA-binding domains, they regulate gene transcription. Upon entering the relevant cellular environment, GSK 4716 interacts with the ligand-binding domains of ERRβ/ERRγ, inducing a conformational change in the receptors and promoting their transition to an active state. Once activated, ERRβ/ERRγ recognize specific DNA regulatory regions and modulate transcription, thereby altering the expression levels of downstream target genes. Thus, GSK 4716 does not act directly on a specific metabolite; instead, by activating nuclear receptors, it transduces an exogenous small-molecule signal into a regulatory signal at the level of gene transcription.

2. Regulation of Downstream Gene Transcription

Upon activation of ERRβ/ERRγ by GSK 4716, the receptors form complexes with relevant transcriptional regulators and help control downstream gene expression. The ERR family recognizes specific DNA response elements and modulates target-gene transcription through mechanisms such as co-activator recruitment. By enhancing ERRβ/ERRγ transcriptional activity, GSK 4716 further influences gene networks associated with cellular metabolism, energy utilization, and mitochondrial function. This mechanism represents a classic form of nuclear receptor-mediated transcriptional regulation, acting at the level of gene expression rather than merely altering the intracellular concentration of a specific signaling molecule. The resulting downstream changes are systemic and can affect multiple interconnected biological processes.

3. Modulation of Pathways Related to Energy Metabolism

Upon activation of ERRβ/ERRγ, GSK 4716 further modulates regulatory networks associated with cellular energy metabolism and mitochondrial function. The ERR family is closely linked to oxidative metabolism, lipid utilization, glucose metabolism, and the expression of mitochondria-related genes; consequently, changes in ERR activity propagate across multiple metabolic processes. By modulating the transcriptional activity of ERRβ/ERRγ, GSK 4716 alters the regulation of metabolic genes governed by these receptors, thereby influencing cellular energy substrate utilization and energy production pathways. In terms of the overall mechanism, the process can be summarized as follows: GSK 4716 binds to ERRβ/ERRγ → alters receptor conformation and activity → modulates transcription factors and coregulators → changes the expression of downstream metabolic genes → impacts cellular energy metabolism networks.

Xi'an Sonwu Biotech Co., Ltd. has established a complete technology platform covering peptide molecular design, custom synthesis, precision purification, structural identification, and quality control. Strictly adhering to international quality management standards, the company ensures its peptide raw materials meet overseas customers' high-end requirements for purity, stability, and batch consistency.

In the future, Sonwu plans to continue advancing peptide technological innovation, broaden its network of international collaborators, and strive to establish itself as a reliable, long-term supplier of peptide raw material solutions to clients worldwide.

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1. Which receptors does GSK 4716 primarily act upon?

GSK 4716 primarily acts on estrogen-related receptor beta (ERRβ) and estrogen-related receptor gamma (ERRγ), exhibiting significant agonist activity toward both receptors. ERRβ and ERRγ belong to the nuclear receptor family and play important roles in energy metabolism and the regulation of cellular functions.

2. What effects does GSK 4716 have on energy metabolism?

ERRβ and ERRγ are involved in various energy-metabolism processes, including oxidative metabolism, fatty acid utilization, and mitochondrial functions. By modulating ERRβ/ERRγ activity, GSK 4716 influences associated metabolic signaling and gene expression; consequently, its effects are closely linked to cellular energy balance.

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