O 304 Powder

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O 304 powder, (also known as ATX 304) is a first-in-class, orally active pan-AMPK activator, a drug candidate with potential for treating type 2 diabetes (T2D), cardiovascular diseases, heart failure, and chronic kidney disease, acting as an "exercise mimetic" by improving metabolism and blood flow, showing promise in clinical trials by reducing glucose levels and insulin resistance, and protecting against obesity-related issues in preclinical studies.ATX 304, supplied for research and formulation purposes, contains this advanced pan-AMPK activator and is widely used in metabolic and cardiovascular research. As ATX 304 powder, it continues to attract attention for its role in improving metabolic efficiency, enhancing insulin sensitivity, and supporting healthy energy homeostasis. As you can see, this product is being used more and more widely in the market. If you are interested in O 304 suppliers , you can contact Xi'an Sonwu Biotech Co., Ltd.

Xi'an Sonwu Biotech Co., Ltd is a peptide raw material supplier with peptide technology at its core and an international market orientation. Xi'an Sonwu specialize in the R&D, production, and global supply of functional peptides and polypeptide raw materials, serving multiple application areas including muscle building, beauty, hair growth, weight management, nootropics and pharmaceuticals raw materials.

Xi'an Sonwu products have been widely used in the R&D and industrialization projects of customers worldwide.Based on this, Xi'an Sonwu have received a lot of feedback on our products. Therefore, if you need it, please contact us.

Xi'an Sonwu not only provides large-scale production services but can also provide sample packages to customers first.

Xi'an Sonwu not only can supply high quality raw ATX 304 powder, but also supplies capsules.

So any customers could customize capsules they want. And items below can be supplied.

1. Customized capsule shells (size, color, material)

2. Customized bottles(size, color, material, style)

3. Customized packaging(vacuum foil packaging, box, drum)

4. Customized label(paint film, matte film, optical mask)

1. Metabolic Health Enhancement

O 304 powder demonstrates robust potential in metabolic health enhancement. In preclinical and clinical studies, it supports type 2 diabetes management by reducing fasting plasma glucose levels and insulin resistance (HOMA-IR), and by improving insulin sensitivity through stimulation of insulin-independent glucose uptake in skeletal muscle and cardiac tissue. In addition, it helps protect pancreatic β-cells by alleviating cellular stress and promoting β-cell rest, thereby supporting long-term pancreatic function. It also exhibits anti-obesity potential by stimulating brown adipose tissue activation to increase energy expenditure via thermogenesis, while helping prevent diet-induced fatty liver disease.

2. Cardiovascular Benefits

It offers notable cardiovascular benefits. Studies indicate that it helps regulate blood pressure in animal models and individuals with type 2 diabetes, while enhancing microvascular perfusion to support peripheral circulation and overall microvascular function. Furthermore, ATX 304 improves cardiac performance by increasing stroke volume and cardiac output without inducing cardiac hypertrophy. It also contributes to the prevention of atherosclerosis by reducing vascular inflammation and oxidative stress, and supports renal function by promoting efficient energy metabolism and autophagy.

3. Aging and Longevity Research

It also shows great potential in aging and longevity research. ATX 304 powder helps maintain mitochondrial homeostasis to restore cellular energy metabolism and preserve mitochondrial function, promotes autophagy to support cellular cleanup and removal of damaged components, and regulates key anti-aging gene pathways to down regulate cellular senescence and DNA damage responses.Mechanistically, It acts as a pan-AMPK activator to regulate cellular energy homeostasis and metabolic signaling pathways.

ATX 304 exerts its unique biological effects through a unique mechanism, which distinguishes it from traditional AMPK activators, giving it a well-defined and targeted pathway of action

Direct AMPK Activation
Unlike indirect AMPK activators that rely on inducing cellular stress or ATP depletion, ATX 304 directly binds to AMPK and suppresses the dephosphorylation of pAMPK (the phosphorylated, active form of AMPK). This mechanism allows sustained AMPK activation without compromising intracellular ATP levels, ensuring effective energy-sensing signaling while avoiding cellular energy deficiency. As a result, It achieves stable metabolic regulation without triggering stress-related compensatory responses.

Metabolic Demand Generation
ATX 304 functions as a mild mitochondrial uncoupled, increasing cellular metabolic demand and enhancing energy turnover. By elevating energy expenditure without inducing mitochondrial toxicity, this mechanism closely mimics the physiological effects of physical exercise, supporting improved metabolic flexibility and endurance-like adaptations without the need for actual physical activity.

Pan AMPK Mediated Metabolic Regulation

O-304 functions through a comprehensive pan-AMPK activation profile, engaging all major AMPK isoforms (α1/α2, β1/β2, and γ1/γ2/γ3) and enabling coordinated metabolic regulation across multiple metabolically active tissues, including skeletal muscle, liver, pancreas, heart, and vascular systems. By centrally activating AMPK signaling, O-304 influences multiple downstream metabolic pathways: it supports glucose uptake through the upregulation of glucose transporter expression (such as GLUT4), enhances fatty acid oxidation to limit ectopic lipid accumulation, and regulates glycogen storage to maintain metabolic balance. At the cellular level, this AMPK-centered signaling promotes mitochondrial biogenesis, improving energy production capacity, while simultaneously modulating inflammatory and oxidative stress–related pathways. Together, these integrated effects contribute to improved cellular resilience, vascular function, and systemic metabolic homeostasis, highlighting the broad research relevance of O-304.

Based on preclinical studies and early clinical trials, O 304 demonstrates a favorable safety profile with no serious adverse events reported. In individual cases, It may be associated with mild and transient side effects, primarily including minor gastrointestinal discomfort (such as nausea or abdominal distension) and occasional dizziness. These effects are generally well tolerated and tend to resolve spontaneously without the need for specific intervention.

Importantly, in multiple controlled preclinical evaluations, O-304 powder has been assessed using standard safety-related endpoints relevant to AMPK-targeted compounds. Across repeated-dose studies conducted at research-relevant exposure levels, no increases in heart weight indices, cardiomyocyte size, or other markers associated with cardiac hypertrophy were observed, distinguishing it from certain AMPK activators known to raise such concerns.

In parallel, systemic safety assessments including organ weight analysis, histopathological examination, and basic biochemical markers showed no treatment-related abnormalities in major organs such as the liver, kidneys, or pancreas under controlled experimental conditions.

1. Xi'an Sonwu Biotech Co . Itd has established a complete technology platform, covering peptide molecular design, custom synthesis, precision purification, structural identification, and quality control.

2. It strictly adheres to international quality management standards, ensuring that its peptide raw materials meet the high-end requirements of overseas customers in terms of purity, stability, and batch consistency.

3. Looking to the future, it will continue to deepen peptide technology innovation, expand the global cooperation network, and strive to become a trusted long-term peptide raw material solution partner for international customers.

HALAL

HACCP

CERES

ISO9001

ISO14001

ISO9001

 

In addition to guaranteeing the product quality, the other most vital thing is clients could receive the goods smoothly. So, Xi'an Sonwu supply all kinds of couriers according to different needs.

One of the key features of O 304 is its targeted AMPK-activating effect, but this biological activity also carries a risk of side effects, especially with prolonged or high-dose use.

Common risks include

restlessness and mild agitation

transient dizziness or fatigue

gastrointestinal discomfort, such as nausea and abdominal distension

rare skin pruritus or scattered erythema

transient mild elevation of liver function indicators

rebound fatigue after the effect subsides

The severity of these side effects varies from person to person, and without professional medical supervision, users bear all associated risks.

If you want to find a ATX 304 supplier, contact Xi'an Sonwu. Click the email, and then you get high-quality O 304 powder.

If you want to find a ATX 304 supplier, contact Xi'an Sonwu. Click the email, and then you get high-quality O 304 powder or capsule.

Email: sales02@sonwu.com

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